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Itgb3tm1Hyn
Targeted Allele Detail
Nomenclature
Symbol: Itgb3tm1Hyn
Name: integrin beta 3; targeted mutation 1, Richard Hynes
MGI ID: MGI:2175913
Synonyms: beta3-, Beta3, beta3 KO
Gene: Itgb3  Location: Chr11:104608000-104670476 bp, + strand  Genetic Position: Chr11, 67.84 cM
Survival of Itgb3tm1Hyn/Itgb3tm1Hyn mice is compromised due to placental defects and hemorrhage

Show the 2 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52262
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Itgb3 Mutation:  8 strains or lines available
References
Original:  J:52262 Hodivala-Dilke KM, et al., Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999 Jan;103(2):229-38
All:  77 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory