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Gabbr1tm1Bet
Targeted Allele Detail
Nomenclature
Symbol: Gabbr1tm1Bet
Name: gamma-aminobutyric acid (GABA) B receptor, 1; targeted mutation 1, Bernhard Bettler
MGI ID: MGI:2159352
Synonyms: GABAB(1)-, GB1-
Gene: Gabbr1  Location: Chr17:37045966-37074305 bp, + strand  Genetic Position: Chr17, 19.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70558
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 7-10. In situ hybridization experiments on brain sections of homozygous mice confirmed that no detectable transcript was produced from this allele. Western blot and radiolabeled binding assays confirmed that no functional protein was expressed in brain of homozygous mice. (J:70558)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabbr1 Mutation:  57 strains or lines available
References
Original:  J:70558 Schuler V, et al., Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron. 2001 Jul 19;31(1):47-58
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory