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Neurod6tm1Kan
Targeted Allele Detail
Nomenclature
Symbol: Neurod6tm1Kan
Name: neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:2159008
Synonyms: NEX -
Gene: Neurod6  Location: Chr6:55677818-55681263 bp, - strand  Genetic Position: Chr6, 27.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45777
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing most of the coding region, including amino acids 53-337 encoding the bHLH domain. Northern blot analysis on brain RNA derived from P5 homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:45777)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurod6 Mutation:  1 strain or line available
References
Original:  J:45777 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J Neurosci. 1998 Feb 15;18(4):1408-18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory