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Targeted Allele Detail
Symbol: Ercc1tm1Dwm
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1; targeted mutation 1, David W Melton
MGI ID: MGI:2158940
Synonyms: Ercc1-, ERCC-1 -
Gene: Ercc1  Location: Chr7:19344778-19356524 bp, + strand  Genetic Position: Chr7, 9.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:15422
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene was inserted into exon 5. Northern blot analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:15422)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc1 Mutation:  13 strains or lines available
Original:  J:15422 McWhir J, et al., Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning [see comments]. Nat Genet. 1993 Nov;5(3):217-24
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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