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Targeted Allele Detail
Symbol: Triotm1Mst
Name: triple functional domain (PTPRF interacting); targeted mutation 1, Michel Streuli
MGI ID: MGI:2158695
Synonyms: trio-
Gene: Trio  Location: Chr15:27730651-28025848 bp, - strand  Genetic Position: Chr15, 10.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:65380
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette was inserted into sequences encoding the amino-terminal GEF domain. Western blot analysis on immunoprecipitates of E14.5 embryonic cells derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:65380, J:112170)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trio Mutation:  68 strains or lines available
Original:  J:65380 O'Brien SP, et al., Skeletal muscle deformity and neuronal disorder in trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12074-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory