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Targeted Allele Detail
Symbol: Npr1tm1(Npr1)Unc
Name: natriuretic peptide receptor 1; targeted mutation 1, University of North Carolina
MGI ID: MGI:2158630
Synonyms: Npr1tm1(Npr1)Smi
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:46175
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Npr1tm1(Npr1)Unc expresses 1 gene
Mutation detailsA gap-repair vector was used to induce a tandem duplication of the gene. Guanylate cyclase activity assays demonstrated a correlation of increased activity to gene dosage in heterozygous and homozygous mice. (J:46175)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  26 strains or lines available
Original:  J:46175 Oliver PM, et al., Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2547-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory