Phenotypes associated with this allele

• Allele Symbol: Npr1^tm1(Npr1)Unc
• Allele Name: targeted mutation 1, University of North Carolina
• Allele ID: MGI:2158630
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npr1^tm1(Npr1)Unc/Npr1^tm1(Npr1)Unc	involves: 129P2/OlaHsd * C57BL/6	MGI:3664254
ht2	Npr1^tm1(Npr1)Unc/Npr1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3664253

Genotype
MGI:3664254

hm1

• Allelic Composition: Npr1^tm1(Npr1)Unc/Npr1^tm1(Npr1)Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial blood pressure ( J:46175 )

• show a significant decrease in blood pressure (by 6.9 mmHg) as dietary salt is increased from 0.05% to 8%

homeostasis/metabolism

increased circulating testosterone level ( J:58344 )

• serum testosterone level is 144% of that in wild-type

endocrine/exocrine glands

abnormal sex gland physiology ( J:58344 )

• Leydig cells show nearly twice as high atrial natriuretic peptide (ANP)-dependent testosterone production and cGMP accumulation

reproductive system

abnormal sex gland physiology ( J:58344 )

• Leydig cells show nearly twice as high atrial natriuretic peptide (ANP)-dependent testosterone production and cGMP accumulation

Genotype
MGI:3664253

ht2

• Allelic Composition: Npr1^tm1(Npr1)Unc/Npr1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

decreased systemic arterial blood pressure ( J:46175 )

• males exhibit blood pressures an average of 5.2 mmHg below controls

• similar to wild-type, dietary salt does not affect blood pressure