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Prf1tm1Tsc
Targeted Allele Detail
Nomenclature
Symbol: Prf1tm1Tsc
Name: perforin 1 (pore forming protein); targeted mutation 1, Jurg Tschopp
MGI ID: MGI:2158418
Synonyms: Kagi, Prf1-
Gene: Prf1  Location: Chr10:61297836-61304263 bp, + strand  Genetic Position: Chr10, 32.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21731
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 3. RT-PCR and Northern blot analysis on splenoctye RNA derived from homozygous mice demonstrated that no transcript was produced from this allele. (J:21731)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prf1 Mutation:  9 strains or lines available
References
Original:  J:21731 Lowin B, et al., A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11571-5
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory