All Phenotypes Prf1<tm1Tsc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prf1^tm1Tsc
targeted mutation 1, Jurg Tschopp
MGI:2158418

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prf1^tm1Tsc/Prf1^tm1Tsc	129X1.129S2-Prf1^tm1Tsc	MGI:4354612
hm2	Prf1^tm1Tsc/Prf1^tm1Tsc	involves: 129S2/SvPas	MGI:4354595
ht3	Prf1^tm1Tsc/Prf1⁺	involves: 129S2/SvPas	MGI:4354596

Allelic Composition	Prf1^tm1Tsc/Prf1^tm1Tsc
Genetic Background	129X1.129S2-Prf1^tm1Tsc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1^tm1Tsc mutation (0 available); any Prf1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:126114 )

• mice challenged with RMAS or B16 tumors exhibit increased lethality compared with similarly treated wild-type mice

immune system

decreased T cell apoptosis ( J:126114 )

• NK and CD8+ T cell death in the tumor ascites from mice transplanted with RMAS cells is decreased compared to that of similarly treated wild-type mice and further decreased after T reg depletion

abnormal NK cell physiology ( J:126114 )

• NK and CD8+ T cell death in the tumor ascites from mice transplanted with RMAS cells is decreased compared to that of similarly treated wild-type mice and further decreased after T reg depletion

neoplasm

increased tumor growth/size ( J:126114 )

• tumor burden in mice challenged with RMAS cells is increased compared to in similarly treated wild-type mice

cellular

decreased T cell apoptosis ( J:126114 )

• NK and CD8+ T cell death in the tumor ascites from mice transplanted with RMAS cells is decreased compared to that of similarly treated wild-type mice and further decreased after T reg depletion

hematopoietic system

decreased T cell apoptosis ( J:126114 )

• NK and CD8+ T cell death in the tumor ascites from mice transplanted with RMAS cells is decreased compared to that of similarly treated wild-type mice and further decreased after T reg depletion

abnormal NK cell physiology ( J:126114 )

• NK and CD8+ T cell death in the tumor ascites from mice transplanted with RMAS cells is decreased compared to that of similarly treated wild-type mice and further decreased after T reg depletion

Allelic Composition	Prf1^tm1Tsc/Prf1^tm1Tsc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1^tm1Tsc mutation (0 available); any Prf1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:21731 )

decreased cytotoxic T cell cytolysis ( J:21731 )

• despite inducing some signs of apoptosis, mice fail to mount a significant cytotoxic T lymphocyte response to target cells unlike similarly treated wild-type mice

• however, an excess of cytolytic cells promotes lysis and exocytosis of cytotoxic granules is normal following incubation with immobilized anti-CD3 antibodies

decreased susceptibility to bacterial infection ( J:50903 )

• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver damage compared with similarly treated wild-type mice

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:50903 )

• following exposure to Pseudomonas aerugiosa exotoxin

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:21731 )

decreased cytotoxic T cell cytolysis ( J:21731 )

• despite inducing some signs of apoptosis, mice fail to mount a significant cytotoxic T lymphocyte response to target cells unlike similarly treated wild-type mice

• however, an excess of cytolytic cells promotes lysis and exocytosis of cytotoxic granules is normal following incubation with immobilized anti-CD3 antibodies

Allelic Composition	Prf1^tm1Tsc/Prf1⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1^tm1Tsc mutation (0 available); any Prf1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:21731 )

• 2-fold lower compared to wild-type cells

decreased cytotoxic T cell cytolysis ( J:21731 )

• cytotoxic T lymphocyte activity is slightly lower than in similarly treated wild-type mice

• however, exocytosis of cytotoxic granules is normal following incubation with immobilized anti-CD3 antibodies

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:21731 )

• 2-fold lower compared to wild-type cells

decreased cytotoxic T cell cytolysis ( J:21731 )

• cytotoxic T lymphocyte activity is slightly lower than in similarly treated wild-type mice

• however, exocytosis of cytotoxic granules is normal following incubation with immobilized anti-CD3 antibodies

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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