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Zmpste24tm1Sgy
Targeted Allele Detail
Nomenclature
Symbol: Zmpste24tm1Sgy
Name: zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young
MGI ID: MGI:2158363
Synonyms: Zmeste24-
Gene: Zmpste24  Location: Chr4:121059237-121098241 bp, - strand  Genetic Position: Chr4, 56.8 cM
CT scans illustrating bony lesions in Zmpste24tm1Sgy/Zmpste24tm1Sgy mice.

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70661
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zmpste24 Mutation:  4 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Osteogenesis Imperfecta (J:106473)

References
Original:  J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory