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Targeted Allele Detail
Symbol: Zmpste24tm1Sgy
Name: zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young
MGI ID: MGI:2158363
Synonyms: Zmeste24-
Gene: Zmpste24  Location: Chr4:120916434-120955438 bp, - strand  Genetic Position: Chr4, 56.8 cM
CT scans illustrating bony lesions in Zmpste24tm1Sgy/Zmpste24tm1Sgy mice.

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:70661
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 8 was replaced with a floxed neomycin selection cassette. Enzymatic activity assays on liver cell membranes derived from homozygous mice demonstrated reduced or absent processing of synthetic substrates, suggesting that no functional protein is produced from this allele. (J:70661)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 27 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zmpste24 Mutation:  25 strains or lines available
Original:  J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory