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Phenotype Image Detail
Image
Caption A-C: Top, lateral and bottom surfaces of the skulls of 8 week old Zmpste24tm1Sgy/Zmpste24tm1Sgy and Zmpste24tm1Sgy/Zmpste24+ mice. Arrowheads show the destroyed zygomatic arch in in A and C; an arrow indicates the small mandible in B. D: Maximal intensity projection of the lateral view of the skulls of 8 week old mice showing an increase in the length of the incisors and size of other teeth. E: Surface rendering of thoracic spines of 8 week old Zmpste24tm1Sgy/Zmpste24tm1Sgy amd Zmpste24tm1Sgy/Zmpste24+ mice showing increased pock marks in the Zmpste24tm1Sgy/Zmpste24tm1Sgy mice. F: Surface rendering of the femur, knee, tibia/fibula of 8 week old Zmpste24tm1Sgy/Zmpste24tm1Sgy and Zmpste24tm1Sgy/Zmpste24+ mice, revealing increased pock marks in the proximal fibula of the Zmpste24tm1Sgy/Zmpste24tm1Sgy mouse as well as effacement of the tibial turerosity.
Copyright This image is from Bergo MO, Proc Natl Acad Sci U S A 2002 Oct 1;99(20):13049-54. Copyright 2002 National Academy of Sciences, U.S.A. J:79501
Associated
Alleles
Symbol Name
Zmpste24tm1Sgy zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young
Associated
Genotypes
Allelic Composition Genetic Background
Zmpste24tm1Sgy/Zmpste24tm1Sgy involves: 129S4/SvJae * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory