About   Help   FAQ
St8sia1tm1Rlp
Targeted Allele Detail
Nomenclature
Symbol: St8sia1tm1Rlp
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; targeted mutation 1, Richard L Proia
MGI ID: MGI:2158360
Synonyms: GD3S -, Siat8a-
Gene: St8sia1  Location: Chr6:142767271-142910178 bp, - strand  Genetic Position: Chr6, 74.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67955
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-lacZ and neomycin selection cassette was inserted into exon 5, which encodes the sialyl S motif, an essential part of the catalytic domain of the encoded protein. TLC analysis on brain extract of homozygous mice demonstrated that no active protein was produced from this allele. (J:67955)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any St8sia1 Mutation:  25 strains or lines available
References
Original:  J:67955 Kawai H, et al., Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J Biol Chem. 2001 Mar 9;276(10):6885-8
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory