About   Help   FAQ
Targeted Allele Detail
Symbol: St8sia1tm1Rlp
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; targeted mutation 1, Richard L Proia
MGI ID: MGI:2158360
Synonyms: GD3S -, Siat8a-
Gene: St8sia1  Location: Chr6:142767271-142910178 bp, - strand  Genetic Position: Chr6, 74.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:67955
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-lacZ and neomycin selection cassette was inserted into exon 5, which encodes the sialyl S motif, an essential part of the catalytic domain of the encoded protein. TLC analysis on brain extract of homozygous mice demonstrated that no active protein was produced from this allele. (J:67955)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any St8sia1 Mutation:  25 strains or lines available
Original:  J:67955 Kawai H, et al., Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J Biol Chem. 2001 Mar 9;276(10):6885-8
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.20
The Jackson Laboratory