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Targeted Allele Detail
Symbol: Igh-Jtm1Dhu
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Dennis Huszar
MGI ID: MGI:2158307
Synonyms: Jh-, JH, JH0, JHD, JHT
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:52448
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsA ~2.3 kb genomic fragment encompassing the four J-H segments and a flanking D-Q52 segment was replaced with a neomycin selection cassette. Homozygous mice do not produce rearranged immunoglobulin heavy chains. (J:52448)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
Homozygous mutant mice do not develop mature B cells (J:97700).
Original:  J:52448 Chen J, et al., Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol. 1993 Jun;5(6):647-56
All:  128 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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