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Targeted Allele Detail
Symbol: Atp1b2tm1Msch
Name: ATPase, Na+/K+ transporting, beta 2 polypeptide; targeted mutation 1, Melitta Schachner
MGI ID: MGI:2157776
Synonyms: AMOG0, AMOG/beta 2-deficient
Gene: Atp1b2  Location: Chr11:69599736-69605942 bp, - strand  Genetic Position: Chr11, 42.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:21121
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the first coding exon. Western blot analysis on crude membrane preparations of brain derived from homozygous mice demonstrated that no encoded protein was detectable. (J:21121)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp1b2 Mutation:  16 strains or lines available
Original:  J:21121 Magyar JP, et al., Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase. J Cell Biol. 1994 Nov;127(3):835-45
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory