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Targeted Allele Detail
Symbol: Apoa4tm1Bres
Name: apolipoprotein A-IV; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2157162
Synonyms: apoA-IV -
Gene: Apoa4  Location: Chr9:46152142-46154756 bp, + strand  Genetic Position: Chr9, 25.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:43015
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.1kb genomic fragment containing exon 1 and intron 1 was replaced with a neomycin selection cassette. No transcript was detectable in northern blot analysis on intestinal RNA from homozygous mice, and western blot analysis demonstrated that no stable protein was detectable in plasma of homozygous mice. (J:43015)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoa4 Mutation:  12 strains or lines available
Original:  J:43015 Weinstock PH, et al., Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res. 1997 Sep;38(9):1782-94
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory