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Apobtm1Bres
Targeted Allele Detail
Summary
Symbol: Apobtm1Bres
Name: apolipoprotein B; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2157090
Gene: Apob  Location: Chr12:8027648-8066835 bp, + strand  Genetic Position: Chr12, 3.53 cM
Alliance: Apobtm1Bres page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29700
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A genomic fragment containing exons 1-3 was replaced with a neomycin selection cassette. (J:29700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apob Mutation:  221 strains or lines available
References
Original:  J:29700 Huang LS, et al., apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest. 1995 Nov;96(5):2152-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory