All Phenotypes Apob<tm1Bres> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apob^tm1Bres
targeted mutation 1, Jan L Breslow
MGI:2157090

Summary

2 genotypes

Allelic Composition	Apob^tm1Bres/Apob^tm1Bres
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apob^tm1Bres mutation (0 available); any Apob mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

Allelic Composition	Apob^tm1Bres/Apob⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apob^tm1Bres mutation (0 available); any Apob mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:35836 )

• mild reduction in sperm count

• decreased sperm viability was observed in vitro

asthenozoospermia ( J:35836 )

• approximately 80% of sperm were immotile

• motile sperm that bound the zona pellucida became immotile

reduced male fertility ( J:35836 )

• 60% were unable to produce offspring

• sperm could bind but not penetrate the zona pellucida