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Targeted Allele Detail
Symbol: Zic2tm1Jaru
Name: zinc finger protein of the cerebellum 2; targeted mutation 1, Jun Aruga
MGI ID: MGI:2156825
Synonyms: Zic2kd
Gene: Zic2  Location: Chr14:122475435-122479852 bp, + strand  Genetic Position: Chr14, 65.97 cM
Neural tube defects found in Zic2tm1Jaru/Zic2tm1Jaru mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:60644
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA gene targeting event was designed to replace the first exon containing the start codon and encoding three of the five zinc fingers. However, unexpected recombination resulted in an allele with reduced expression. The allele retained exon 1 with the neomycin-resistance marker in the first intron, shown by Southern blot. This resulted in reduction (knockdown, kd) of Zic2 expression. (J:60644)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zic2 Mutation:  11 strains or lines available
Original:  J:60644 Nagai T, et al., Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1618-23
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory