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| Caption | A: Lateral views of P0 wild-type (left) and Zic2tm1Jaru/Zic2tm1Jaru (right) newborns. Heads of the homozygous mouse were significantly smaller (microcephaly). Arrowhead, pes equinus; *, spina bifida. B: Dorsal closeup view of P0 homozygous mouse embryo. Spina bifida is observed. C: Lateral close-up view. Tails were irregularly curled. D-G: Transverse sections through thoracic (d & e) and lumbar spinal cord (f & g) of wild-type (d & f) and homozygous mutant (e & g) mouse embryos at E15.5. Dorsal root ganglion (drg); spinal cord (sc); open spinal cord (osc); vertebral body (v). H & I: Scanning electron micrographs show no closure of lumbar spinal cord in the homozygous mouse embryos (i) at E9.5 and successful closure in a wild-type littermate. Posterior neuropore (np). J-S: Holoprosencephaly found in the homozygous mouse embryo. Coronal ( j & k) and parasagittal (l & m) sections through cerebrum of wild-type mouse (j & l) and homozygous mouse (k & m) brain at E15.5. Cerebral cortex (cc) of both hemispheres in the homozygous mutant mouse brain is fused at the dorsal midline, with the single ventricle and the juxtaposed ganglionic eminence (ge)(k). Cerebral cortex and olfactory bulb (ob) of the homozygous mouse brain are hypoplastic (m). Magnified frontal views of head (n & o) and horizontal sections through eye (p-s) of wild-type (n, p, & r) and homozygous mouse (o,q. &s) E10.5 embryo. The telencephalic roof plate region in p and q is magnified in r and s, respectively. Telencephalic roof plate (arrowheads in n, p, and r) is apparently absent in the homozygous mouse (arrowheads in o & q), resulting in the loss of discrimination between left and right telencephalic vesicles. T & U: A typical example of exencephaly found in the E12.5 homozygous mutant mouse embryo. p. lateral view; q, dorsal view. Telencephalic (t); diencephalic (d) and mesencephalic (m) neural plate fail to fuse at the midline. The spinal cord remains open in the lumbosacral region(*). V: Lateral view of a homozygous mutant mouse embryo at E18.5 possessing anecephaly (arrowheads) and spina bifida (*). W: Top view of homozygous mouse embryo in V. In this particular embryo, almost all brain tissue is lost. | ||||
| Copyright | This image is from Nagai T, Proc Natl Acad Sci U S A 2000 Feb 15;97(4):1618-23. Copyright 2000 National Academy of Sciences, U.S.A. J:60644 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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