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Bcl2l11tm1Ast
Targeted Allele Detail
Nomenclature
Symbol: Bcl2l11tm1Ast
Name: BCL2-like 11 (apoptosis facilitator); targeted mutation 1, Andreas Strasser
MGI ID: MGI:2156494
Synonyms: bim-, bimneo
Gene: Bcl2l11  Location: Chr2:128126038-128162547 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58641
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A floxed PGK-neomycin cassette replaced the exon encoding the BH3 domain. (J:58641)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  16 strains or lines available
References
Original:  J:58641 Bouillet P, et al., Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999 Nov 26;286(5445):1735-8
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory