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Il7tm1Hms
Targeted Allele Detail
Nomenclature
Symbol: Il7tm1Hms
Name: interleukin 7; targeted mutation 1, Harvard Medical School
MGI ID: MGI:2156458
Gene: Il7  Location: Chr3:7569994-7613760 bp, - strand  Genetic Position: Chr3, 2.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43971
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance construct was inserted into the EcoRI site of exon 2. This mutation inactivates exon 2 and appears to be null. Ribonuclease protection assays detected no transcript from the thymus or spleen of homozygous mutant animals. (J:43971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il7 Mutation:  19 strains or lines available
References
Original:  J:43971 Rich BE, Autocrine expression of interleukin-7 rescues lymphoid expansion in interleukin-7-deficient mice. Immunology. 1997 Nov;92(3):374-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory