All Phenotypes Il7<tm1Hms> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il7^tm1Hms
targeted mutation 1, Harvard Medical School
MGI:2156458

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il7^tm1Hms/Il7^tm1Hms	involves: 129S6/SvEvTac	MGI:2668582

Allelic Composition	Il7^tm1Hms/Il7^tm1Hms
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7^tm1Hms mutation (2 available); any Il7 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:43971 )

• thymocyte number is 1-5% of wild-type littermates

decreased bone marrow cell number ( J:43971 )

• cell number approximately half of wild-type littermates due to a deficit in B cell lineage cells

spleen hypoplasia ( J:43971 )

• splenic lymphocyte number is less than half of wild-type littermates

immune system

thymus hypoplasia ( J:43971 )

• thymocyte number is 1-5% of wild-type littermates

spleen hypoplasia ( J:43971 )

• splenic lymphocyte number is less than half of wild-type littermates

endocrine/exocrine glands

thymus hypoplasia ( J:43971 )

• thymocyte number is 1-5% of wild-type littermates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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