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Bcl2tm1Dlo
Targeted Allele Detail
Nomenclature
Symbol: Bcl2tm1Dlo
Name: B cell leukemia/lymphoma 2; targeted mutation 1, Dennis Y Loh
MGI ID: MGI:2156165
Synonyms: bcl-2-
Gene: Bcl2  Location: Chr1:106538178-106714274 bp, - strand  Genetic Position: Chr1, 49.76 cM
\AlleleSymbol (MGI:2156165|0)/Bcl2tm1Dlo with littermate control

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73660
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette or a hygromycin resistance cassette replaced most of exon 1, which contains most of the coding region. (J:14685)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:  16 strains or lines available
References
Original:  J:73660 Nakayama K, et al., Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3700-4
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory