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Nbntm1Nus
Targeted Allele Detail
Nomenclature
Symbol: Nbntm1Nus
Name: nibrin; targeted mutation 1, Andre Nussenzweig
MGI ID: MGI:2156049
Synonyms: NBS1-
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68993
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 2kb of gene sequence spanning the promoter, exon 1 (including the translation initiation codon), and 700 bp of intron 1. (J:68993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  38 strains or lines available
References
Original:  J:68993 Zhu J, et al., Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol. 2001 Jan 23;11(2):105-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory