H2ax^tm1Nus
Targeted Allele Detail

Summary

• Symbol: H2ax^tm1Nus
• Name: H2A.X variant histone; targeted mutation 1, Andre Nussenzweig
• MGI ID: MGI:2156048
• Synonyms: H2AX-, H2AX^delta
• Gene: H2ax Location: Chr9:44246012-44247374 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: H2ax^tm1Nus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced an AscI-XhoI segment of coding sequence. (J:73342)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying H2ax^tm1Nus

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2ax Mutation: 7 strains or lines available

References

• Original: J:73342 Petersen S, et al., AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001 Dec 6;414(6864):660-5
• All: 30 reference(s)