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Chemically induced Allele Detail
Symbol: Myo7a816SB
Name: myosin VIIA; shaker 816SB
MGI ID: MGI:2155423
Synonyms: Myo7ash1-2R, sh1816SB, sh1OR-816SB
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Strain of Origin:  BALB/cRl
Allele Type:    Chemically induced (ENU)
Mutations:    Insertion, Inversion
Mutation detailsA 16 nt inversion and substitution of two A nucleotides with a single G resulted in a deletion of ten amino acids in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 63% of the normal level of the protein was expressed. (J:49926)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  77 strains or lines available
Original:  J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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