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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myo7a816SB
shaker 816SB
MGI:2155423
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myo7a816SB/Myo7a816SB involves: BALB/cRl MGI:3587760
hm2
 		Myo7a816SB/Myo7a816SB involves: BALB/cRl * 47BS/Rl MGI:3587763


Genotype
MGI:3587760
hm1
Allelic
Composition		 Myo7a816SB/Myo7a816SB
Genetic
Background		 involves: BALB/cRl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7a816SB mutation (2 available); any Myo7a mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal hair cell morphology ( J:49926 )
• abnormal hair cell development
abnormal hearing physiology ( J:49926 )
• no cochlear electrophysiology responses

nervous system
abnormal hair cell morphology ( J:49926 )
• abnormal hair cell development

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Usher syndrome type 1 DOID:0110826 OMIM:276900
 J:42644




Genotype
MGI:3587763
hm2
Allelic
Composition		 Myo7a816SB/Myo7a816SB
Genetic
Background		 involves: BALB/cRl * 47BS/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7a816SB mutation (2 available); any Myo7a mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal cochlear hair cell stereociliary bundle morphology ( J:46373 )
• disorganized formation of stereocilia rows
• some hair cells with several small clumps of stereocilia
abnormal orientation of cochlear hair cell stereociliary bundles ( J:46373 )
• orientation of rows of cochlear hair cell stereocilia erratic
absent cochlear microphonics ( J:46373 )
• no cochlear microphonics responses
abnormal auditory summating potential ( J:46373 )
• no summating potential responses

nervous system
abnormal cochlear hair cell stereociliary bundle morphology ( J:46373 )
• disorganized formation of stereocilia rows
• some hair cells with several small clumps of stereocilia
abnormal orientation of cochlear hair cell stereociliary bundles ( J:46373 )
• orientation of rows of cochlear hair cell stereocilia erratic
absent cochlear microphonics ( J:46373 )
• no cochlear microphonics responses

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Usher syndrome type 1 DOID:0110826 OMIM:276900
 J:46373




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory