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Targeted Allele Detail
Symbol: Apptm2Cwe
Name: amyloid beta (A4) precursor protein; targeted mutation 2, Charles Weissmann
MGI ID: MGI:2154535
Synonyms: APP_, beta APP 0
Gene: App  Location: Chr16:84952666-85175255 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Germline Transmission:  Earliest citation of germline transmission: J:36648
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Cre-mediated recombination resulted in the deletion of 200kb of the gene, from exon 2 - 17. (J:36648)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  59 strains or lines available
Original:  J:36648 Li ZW, et al., Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells [published erratum appears in Proc Natl Acad Sci U S A 1996 Oct 15;93(21):12052]. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6158-62
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory