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Targeted Allele Detail
Symbol: Sox8tm1Weg
Name: SRY (sex determining region Y)-box 8; targeted mutation 1, Michael Wegner
MGI ID: MGI:2154329
Synonyms: Sox8lacZ
Gene: Sox8  Location: Chr17:25565893-25570686 bp, - strand  Genetic Position: Chr17, 12.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:71578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsIn-frame insertion of a LacZ-neomycin resistance cassette replaced the complete open reading frame and both introns of the gene. RT-PCR and in situ hybridization studies indicate that expression of the LacZ marker replaced endogenous gene expression in homozygous mutant embryos and adult male mice. (J:71578)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 157 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox8 Mutation:  14 strains or lines available
Original:  J:71578 Sock E, et al., Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor sox8. Mol Cell Biol. 2001 Oct;21(20):6951-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory