Phenotypes associated with this allele
Allelic Composition |
Sox8tm1Weg/Sox8tm1Weg
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation
(0 available);
any
Sox8 mutation
(26 available)
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adipose tissue
growth/size/body
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• adult homozygous mice weigh approximately 30% less than controls
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limbs/digits/tail
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• reduced size of several tarsals was noted by P7; small size precludes the ability of tarsals to fuse in the adult
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skeleton
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• reduced size of several tarsals was noted by P7; small size precludes the ability of tarsals to fuse in the adult
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation
(0 available);
any
Sox8 mutation
(26 available)
Sox9tm2Crm mutation
(1 available);
any
Sox9 mutation
(32 available)
Tg(Nr5a1-cre)5Asc mutation
(0 available)
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reproductive system
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• at E18.5, Sertoli cells are absent
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• at E18.5, Leydig cells are absent
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• by E18.5 testes have not descended caudally
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• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
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• 40% of mice undergo sex reversal
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endocrine/exocrine glands
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• at E18.5, Sertoli cells are absent
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• at E18.5, Leydig cells are absent
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• by E18.5 testes have not descended caudally
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation
(0 available);
any
Sox8 mutation
(26 available)
Sox9tm2Crm mutation
(1 available);
any
Sox9 mutation
(32 available)
Tg(Nr5a1-cre)5Asc mutation
(0 available)
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endocrine/exocrine glands
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• at E18.5, Sertoli cells are absent
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• at E18.5, Leydig cells are absent
|
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• by E18.5 testes have not descended caudally
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reproductive system
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• at E18.5, Sertoli cells are absent
|
|
• at E18.5, Leydig cells are absent
|
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• by E18.5 testes have not descended caudally
|
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• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
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• 1 in 3 male mice undergoes sex reversal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation
(0 available);
any
Sox8 mutation
(26 available)
Sox9tm2.1Crm mutation
(0 available);
any
Sox9 mutation
(32 available)
|
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reproductive system
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• at E15.5, male mice have fewer seminiferous tubules
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• 3 of 3 mice exhibit abnormal sex chord development and a clearly outlined coelomic vessel
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• at E15.5, male mice have areas resembling an ovary
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endocrine/exocrine glands
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• at E15.5, male mice have fewer seminiferous tubules
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