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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox8tm1Weg
targeted mutation 1, Michael Wegner
MGI:2154329
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox8tm1Weg/Sox8tm1Weg involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3029468
cn2
 		Sox8tm1Weg/Sox8+
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:3719092
cn3
 		Sox8tm1Weg/Sox8tm1Weg
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:3719091
cx4
 		Sox8tm1Weg/Sox8tm1Weg
Sox9tm2.1Crm/Sox9+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J MGI:3719087


Genotype
MGI:3029468
hm1
Allelic
Composition		 Sox8tm1Weg/Sox8tm1Weg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased total body fat amount ( J:71578 )
• smaller adipose stores

growth/size/body
decreased body weight ( J:71578 )
• adult homozygous mice weigh approximately 30% less than controls

limbs/digits/tail
abnormal tarsal bone morphology ( J:71578 )
• reduced size of several tarsals was noted by P7; small size precludes the ability of tarsals to fuse in the adult

skeleton
abnormal tarsal bone morphology ( J:71578 )
• reduced size of several tarsals was noted by P7; small size precludes the ability of tarsals to fuse in the adult




Genotype
MGI:3719092
cn2
Allelic
Composition		 Sox8tm1Weg/Sox8+
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally
abnormal primary sex determination ( J:89368 )
• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
sex reversal ( J:89368 )
• 40% of mice undergo sex reversal

endocrine/exocrine glands
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally




Genotype
MGI:3719091
cn3
Allelic
Composition		 Sox8tm1Weg/Sox8tm1Weg
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally

reproductive system
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally
abnormal primary sex determination ( J:89368 )
• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
sex reversal ( J:89368 )
• 1 in 3 male mice undergoes sex reversal




Genotype
MGI:3719087
cx4
Allelic
Composition		 Sox8tm1Weg/Sox8tm1Weg
Sox9tm2.1Crm/Sox9+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2.1Crm mutation (0 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:89368 )
• at E15.5, male mice have fewer seminiferous tubules
abnormal primary sex determination ( J:89368 )
• 3 of 3 mice exhibit abnormal sex chord development and a clearly outlined coelomic vessel
sex reversal ( J:89368 )
• at E15.5, male mice have areas resembling an ovary

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:89368 )
• at E15.5, male mice have fewer seminiferous tubules




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory