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Targeted Allele Detail
Symbol: Igf1tm1Dlr
Name: insulin-like growth factor 1; targeted mutation 1, Derek LeRoith
MGI ID: MGI:2152423
Synonyms: IGF-Iflox, IGF-I loxP, LID, LI-IGF-I-
Gene: Igf1  Location: Chr10:87858265-87937042 bp, + strand  Genetic Position: Chr10, 43.7 cM
Igf1tm1Dlr/Igf1tm1Dlr Igfalstm1Yrb/Igfalstm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:49468
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA neomycin cassette and loxP sites were inserted flanking exon 4. The introduction of these mutations had no effect on the normal function of the gene. (J:49468)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:  12 strains or lines available
ES cells = 129/Sv

Original:  J:49468 Liu JL, et al., Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol. 1998 Sep;12(9):1452-62
All:  65 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory