Igf1^tm1Dlr
Targeted Allele Detail

Summary

• Symbol: Igf1^tm1Dlr
• Name: insulin-like growth factor 1; targeted mutation 1, Derek LeRoith
• MGI ID: MGI:2152423
• Synonyms: Igf1^floxed, IGF-I^flox, IGF-I loxP, LID, LI-IGF-I-
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm1Dlr page

Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin cassette and loxP sites were inserted flanking exon 4. The introduction of these mutations had no effect on the normal function of the gene. (J:49468)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 27 strains or lines available

Notes

ES cells = 129/Sv

References

• Original: J:49468 Liu JL, et al., Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol. 1998 Sep;12(9):1452-62
• All: 112 reference(s)