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Targeted Allele Detail
Symbol: Dnah1tm1Ihgg
Name: dynein, axonemal, heavy chain 1; targeted mutation 1, Institut fur Humangenetik
MGI ID: MGI:2151944
Synonyms: MDHC7-
Gene: Dnah1  Location: Chr14:31260375-31323896 bp, - strand  Genetic Position: Chr14, 19.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:69800
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsFour exons encoding the P1-loop region are replaced by a neomycin cassette. Northern blot analysis did not detect a transcript produced from this allele and western blot analysis did not detect DNAHC1 protein in extracts of testis or oviducts from homozygous mice. (J:69800)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnah1 Mutation:  87 strains or lines available
Original:  J:69800 Neesen J, et al., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet. 2001 May 15;10(11):1117-28
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory