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Dnah1tm1Ihgg
Targeted Allele Detail
Nomenclature
Symbol: Dnah1tm1Ihgg
Name: dynein, axonemal, heavy chain 1; targeted mutation 1, Institut fur Humangenetik
MGI ID: MGI:2151944
Synonyms: MDHC7-
Gene: Dnah1  Location: Chr14:31260375-31323896 bp, - strand  Genetic Position: Chr14, 19.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69800
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsFour exons encoding the P1-loop region are replaced by a neomycin cassette. Northern blot analysis did not detect a transcript produced from this allele and western blot analysis did not detect DNAHC1 protein in extracts of testis or oviducts from homozygous mice. (J:69800)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnah1 Mutation:  65 strains or lines available
References
Original:  J:69800 Neesen J, et al., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet. 2001 May 15;10(11):1117-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory