Phenotypes associated with this allele

• Allele Symbol: Dnah1^tm1Ihgg
• Allele Name: targeted mutation 1, Institut fur Humangenetik
• Allele ID: MGI:2151944
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnah1^tm1Ihgg/Dnah1^tm1Ihgg	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3041941

Genotype
MGI:3041941

hm1

• Allelic Composition: Dnah1^tm1Ihgg/Dnah1^tm1Ihgg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

asthenozoospermia ( J:69800 )

♂ • spermatozoa exhibited reduced motility and only 1% exhibited forward motility

♂ • total curvilinear and average path velocities were reduced

♂ • lateral amplitude of the sperm tail beat was reduced, and the flagellar beat frequency was increased

♂ • no defect in the axonemal structure of the sperm flagella were seen

male infertility ( J:69800 )

♂ • no offspring were obtained in crosses with homozygous males

respiratory system

abnormal respiratory system physiology ( J:69800 )

• the beat frequency of the tracheal cilia was reduced, but cilia movement took place in a coordinated manner

cellular

asthenozoospermia ( J:69800 )

♂ • spermatozoa exhibited reduced motility and only 1% exhibited forward motility

♂ • total curvilinear and average path velocities were reduced

♂ • lateral amplitude of the sperm tail beat was reduced, and the flagellar beat frequency was increased

♂ • no defect in the axonemal structure of the sperm flagella were seen