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Hoxa4tm1Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxa4tm1Mrc
Name: homeobox A4; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:2150391
Synonyms: hoxa-4-
Gene: Hoxa4  Location: Chr6:52189671-52191753 bp, - strand  Genetic Position: Chr6, 25.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19219
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 1.5 kb of genomic DNA between sequences that encode the recognition helix of the homeodomain and a point 3' to the stop codon. No mRNA was detected by RT-PCR analysis on RNA derived from E12.5 embryos. (J:19219)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa4 Mutation:  2 strains or lines available
References
Original:  J:19219 Kostic D, et al., Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev. 1994 Jun;46(3):231-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory