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Aqp5tm1Ask
Targeted Allele Detail
Nomenclature
Symbol: Aqp5tm1Ask
Name: aquaporin 5; targeted mutation 1, Alan S Verkman
MGI ID: MGI:2150059
Synonyms: AQP5-
Gene: Aqp5  Location: Chr15:99591028-99594829 bp, + strand  Genetic Position: Chr15, 56.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56302
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.8kb neomycin resistance cassette replaced parts of exon 2 and 4, all of exon 3, and all of introns 2 and 3. Northern blots of submandibular gland homogenates from homozygous mutant mice showed no detectable full-length Aqp5 transcripts. Immunocytochemistry of the salivary glands from homozygous mutant mice showed no detectable Aqp5 protein. (J:56302)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:  8 strains or lines available
References
Original:  J:56302 Ma T, et al., Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999 Jul 16;274(29):20071-4
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory