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Juntm1Wag
Targeted Allele Detail
Nomenclature
Symbol: Juntm1Wag
Name: jun proto-oncogene; targeted mutation 1, Erwin F Wagner
MGI ID: MGI:2149630
Synonyms: c-jun-
Gene: Jun  Location: Chr4:95049036-95052222 bp, - strand  Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
Juntm1Wag/Juntm1Wag fetuses exhibit increased apoptosis in the liver

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:14538
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 703 bp of sequence that codes for the DNA binding and leucine zipper domains. Western blot analysis of E9.5 lysates did not detect wild-type protein in homozygous mutant embryos. (J:14538)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 40 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jun Mutation:  6 strains or lines available
Notes
ES cell line = D3-2. Mutant ES cells failed to contribute to the liver but not to other tissues of adult chimeric mice (J:14538). A developmental analysis of chimeras showed contribution of mutant ES cell derivatives to fetal, but not to adult livers, suggesting a role in hepatocyte turnover (J:55508).
References
Original:  J:14538 Hilberg F, et al., c-jun is essential for normal mouse development and hepatogenesis [published erratum appears in Nature 1993 Nov 25;366(6453):368]. Nature. 1993 Sep 9;365(6442):179-81
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory