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Targeted Allele Detail
Symbol: Scaptm1Mbjg
Name: SREBF chaperone; targeted mutation 1, Joseph L Goldstein
MGI ID: MGI:2148743
Synonyms: Scap-, SCAPflox, Scaptm1Gsn
Gene: Scap  Location: Chr9:110333288-110384946 bp, + strand  Genetic Position: Chr9, 59.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:69592
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA a loxP-flanked neomycin resistance cassette located 3 kb upstream of exon 1. An additional loxP site was inserted in intron 1. (J:69592)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scap Mutation:  14 strains or lines available
Original:  J:69592 Matsuda M, et al., SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001 May 15;15(10):1206-16
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory