About   Help   FAQ
Pon1tm1Lus
Targeted Allele Detail
Nomenclature
Symbol: Pon1tm1Lus
Name: paraoxonase 1; targeted mutation 1, Aldons J Lusis
MGI ID: MGI:2148702
Synonyms: PON10
Gene: Pon1  Location: Chr6:5168090-5193946 bp, - strand  Genetic Position: Chr6, 1.99 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63392
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 is disrupted with a neomycin resistance gene via homlogous recombination. Plasma from homozygous mutant animals did not demonstrate paraoxonase activity and did not contain protein product as assayed by Western blot. (J:63392)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pon1 Mutation:  9 strains or lines available
References
Original:  J:63392 Shih DM, et al., Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998 Jul 16;394(6690):284-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory