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Pon1tm1Lus
Targeted Allele Detail
Nomenclature
Symbol: Pon1tm1Lus
Name: paraoxonase 1; targeted mutation 1, Aldons J Lusis
MGI ID: MGI:2148702
Synonyms: PON10
Gene: Pon1  Location: Chr6:5168090-5193946 bp, - strand  Genetic Position: Chr6, 1.99 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63392
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 is disrupted with a neomycin resistance gene via homlogous recombination. Plasma from homozygous mutant animals did not demonstrate paraoxonase activity and did not contain protein product as assayed by Western blot. (J:63392)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pon1 Mutation:  9 strains or lines available
References
Original:  J:63392 Shih DM, et al., Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998 Jul 16;394(6690):284-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory