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Ptgirtm1Sna
Targeted Allele Detail
Summary
Symbol: Ptgirtm1Sna
Name: prostaglandin I receptor (IP); targeted mutation 1, Shuh Narumiya
MGI ID: MGI:2137832
Synonyms: IP-, IPKO
Gene: Ptgir  Location: Chr7:16640442-16644828 bp, + strand  Genetic Position: Chr7, 9.15 cM
Alliance: Ptgirtm1Sna page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42275
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 2.4kb of sequence containing parts of the putative exons II and III, which encode the sixth transmembrane domain. A functional assay did not detect the protein in homozygous mutant mice. (J:42275)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ptgirtm1Sna
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgir Mutation:  32 strains or lines available
Notes

Loss of Ptgir was shown functionally: e.g., a prostacyclin analogue (cicaprost) was used to inhibit platelet aggregation induced by ADP (platelet aggregation was inhibited in wild-type mice, but not in homozygous mutant mice), relaxation of smooth muscle in aortic rings of wild-type and homozygous mutant mice was measured after stimulation with a prostacyclin analogue (cicaprost, again, homozygous mutant mice showed no relaxation upon stimulation). Specificity of the knock-out was demonstrated by functional assay using other prostaglandins (e.g., PGE2). No differences between wild-type and homozygous mutant deficient mice were seen in response to PGE2.

References
Original:  J:42275 Murata T, et al., Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 1997 Aug 14;388(6643):678-82
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory