Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation
(1 available);
any
Ptgir mutation
(32 available)
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immune system
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N |
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation
(1 available);
any
Ptgir mutation
(32 available)
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mortality/aging
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N |
• homozygotes that survive to birth grow normally, are fertile and live >1 year in the absence of overt abnormalities
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• breeding of heterozygotes produces homozygotes at a lower frequency than the predicted Mendelian ratio, suggesting embryonic loss esp. in males
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homeostasis/metabolism
immune system
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• in the carrageenin-induced paw-edema model, homozygotes exhibit reduced edema formation similar to that observed in indomethacin-pretreated wild-type mice
• in addition, homozygotes display a marked reduction of exudate volume in the carrageenin-induced pleurisy model
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behavior/neurological
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• in the acetic acid-induced writhing test, homozygotes exhibit reduced nociceptive perception to levels noted in indomethacin-pretreated wild-type mice
• notably, prostacyclin induces a writhing response in 60% of wild-type mice and in 0% of mutant mice, whereas PGE2 induces a response in less than 25% of animals in both genotypes
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cardiovascular system
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N |
• under basal conditions, homozygotes are normotensive and exhibit a normal heart rate and normal bleeding times relative to wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes exhibit an increased % of luminal stenosis relative to wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes exhibit enhanced vascular proliferative indices, as shown by a significant increase in the intima-to-media ratio, % of luminal stenosis, and the number of intimal and medial BrdU-labeled cells relative to wild-type mice
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hematopoietic system
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• in response to catheter-induced carotid vascular injury, homozygotes display enhanced platelet activation, as shown by an increased injury-related increment in urinary excretion of metabolite 2,3-dinor-TxB2
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation
(1 available);
any
Ptgir mutation
(32 available)
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neoplasm
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N |
• 9-week-old males treated with colon carcinogen azoxymethane exhibit no significant differences in the numbers of aberrant crypt (AC) foci per colon or ACs per focus relative to wild-type counterparts
• ACF formation in the distal colon is associated with a slight increase in spleen weight
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgirtm1Sna mutation
(1 available);
any
Ptgir mutation
(32 available)
Tbxa2rtm1Cof mutation
(0 available);
any
Tbxa2r mutation
(17 available)
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cardiovascular system
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N |
• following catheter-induced carotid vascular injury, double homozygotes fail to exhibit the enhanced vascular proliferative response observed in Ptgirtm1Sna homozygotes
• in double homozygotes, the intima-to-media ratio, % of luminal stenosis, and the number of BrdU-labeled cells is comparable to observed in wild-type mice; in addition, the periprocedural increment in platelet activation noted in Ptgirtm1Sna homozygotes is abolished
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Analysis Tools
