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Gja8tm1Scr
Targeted Allele Detail
Nomenclature
Symbol: Gja8tm1Scr
Name: gap junction protein, alpha 8; targeted mutation 1, The Scripps Institute
MGI ID: MGI:2137525
Synonyms: alpha8(-), Gja8m1
Gene: Gja8  Location: Chr3:96820882-96833336 bp, - strand  
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73651
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene, followed by a neomycin selection cassette, was inserted in-frame after the sixth codon. Western blot analysis demonstrated that no GJA8 protein is detectable in lens homogenates derived from homozygous mice. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:73651)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja8 Mutation:  24 strains or lines available
References
Original:  J:73651 Rong P, et al., Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development. 2002 Jan;129(1):167-74
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory