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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja8tm1Scr
targeted mutation 1, The Scripps Institute
MGI:2137525
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gja8L1/Gja8tm1Scr involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3811921
ht2
 		Gja8R205G/Gja8tm1Scr involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J MGI:5489761
ht3
 		Gja8Lop10/Gja8tm1Scr involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J MGI:3848970
cx4
 		Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8tm1Scr 		involves: 129 * C3H/HeJ * C57BL/6J MGI:3811922
cx5
 		Gja3tm1Scr/Gja3tm1Scr
Gja8tm1Scr/Gja8tm1Scr 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3811924


Genotype
MGI:3811921
ht1
Allelic
Composition		 Gja8L1/Gja8tm1Scr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:108522 )
N
• lack cysts in lens
total cataract ( J:108522 )
• whole cataracts




Genotype
MGI:5489761
ht2
Allelic
Composition		 Gja8R205G/Gja8tm1Scr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Microphthalmia and small lenses with dense nuclear cataracts in Gja8R205G/Gja8tm1Scr mice

vision/eye




Genotype
MGI:3848970
ht3
Allelic
Composition		 Gja8Lop10/Gja8tm1Scr
Genetic
Background		 involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8Lop10 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:75387 )
• dense cataracts by 3 weeks of age




Genotype
MGI:3811922
cx4
Allelic
Composition		 Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8tm1Scr
Genetic
Background		 involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:108522 )
N
• normal lens fiber cell elongation
nuclear cataract ( J:108522 )
• large nuclear cataracts 3 weeks of age




Genotype
MGI:3811924
cx5
Allelic
Composition		 Gja3tm1Scr/Gja3tm1Scr
Gja8tm1Scr/Gja8tm1Scr
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:108522 )
N
• normal lens fiber cell elongation
nuclear cataract ( J:108522 )
• large nuclear cataracts 3 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory