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Targeted Allele Detail
Symbol: Aplp2tm1Dbo
Name: amyloid beta (A4) precursor-like protein 2; targeted mutation 1, David R Borchelt
MGI ID: MGI:2137246
Synonyms: APLP2-
Gene: Aplp2  Location: Chr9:31149557-31211815 bp, - strand  Genetic Position: Chr9, 16.66 cM, cytoband A2-B
Neuromuscular synapse defects in Apptm3.1Zhe/Apptm3.1Zhe Aplp2tm1Dbo/Aplp2tm1Dbo mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:45851
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of the promoter region and first exon with a neomycin cassette. Western blot analysis on samples derived from nervous tissue and other peripheral tissues of homozygous mutant mice failed to detect any protein. (J:45851)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aplp2 Mutation:  5 strains or lines available
Original:  J:45851 von Koch CS, et al., Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997 Nov-Dec;18(6):661-9
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory