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Gdnftm1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Gdnftm1Bbd
Name: glial cell line derived neurotrophic factor; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:2136844
Synonyms: GdnfLacZ, GDNF/lacZ
Gene: Gdnf  Location: Chr15:7811011-7837575 bp, + strand  Genetic Position: Chr15, 3.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33809
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene was inserted in-frame into the first coding exon. A neomycin resistance cassette was also inserted following the lacZ gene. This allele expresses a fusion protein consisting of the first 8 amino acids of GDNF fused to beta-galactosidase. (J:33809)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdnf Mutation:  5 strains or lines available
References
Original:  J:33809 Sanchez MP, et al., Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):70-3
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory