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Il18r1tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Il18r1tm1Aki
Name: interleukin 18 receptor 1; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2136765
Synonyms: Il18r1-, Il18ralpha-, Il1rrptm1Aki
Gene: Il18r1  Location: Chr1:40465552-40500853 bp, + strand  Genetic Position: Chr1, 19.27 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70298
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of the exon encoding amino acids 296-350, encoding the transmembrane region, with a neomycin cassette. No mRNA was detected in liver from homozygous mutant animals, as assayed by RT-PCR. (J:70298)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il18r1 Mutation:  21 strains or lines available
References
Original:  J:70298 Hoshino K, et al., Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol. 1999 May 1;162(9):5041-4
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory