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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il18r1tm1Aki
targeted mutation 1, Shizuo Akira
MGI:2136765
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il18r1tm1Aki/Il18r1tm1Aki either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3589018


Genotype
MGI:3589018
hm1
Allelic
Composition		 Il18r1tm1Aki/Il18r1tm1Aki
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il18r1tm1Aki mutation (1 available); any Il18r1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:70298 )
• impaired lytic activity against pathogens
abnormal T-helper 1 physiology ( J:70298 )
• reduced production of IFN-gamma by Th1 cells in response to bacterial antigen
decreased interferon-gamma secretion ( J:70298 )
• reduced production of IFN-gamma by Th1 cells in response to bacterial antigen

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:70298 )
• impaired lytic activity against pathogens
abnormal T-helper 1 physiology ( J:70298 )
• reduced production of IFN-gamma by Th1 cells in response to bacterial antigen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory