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Gja3tm1Scr
Targeted Allele Detail
Nomenclature
Symbol: Gja3tm1Scr
Name: gap junction protein, alpha 3; targeted mutation 1, The Scripps Research Institute
MGI ID: MGI:2136656
Synonyms: alpha3-, alpha3Cx46-, Cx46lacZ, Gja3tm1
Gene: Gja3  Location: Chr14:57271917-57295487 bp, - strand  Genetic Position: Chr14, 29.82 cM
Dense nuclear cataracts in Gja8R205G/Gja8R205G and Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mice but degenerating peripheral lens fibers only in Gja8R205G/Gja8R205G mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44949
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA DNA fragment encoding the four putative transmembrane domains was replaced with a lacZ gene and a neomycin cassette. No mRNA was expressed by this allele, as assessed by Northern blot on total RNA derived from homozygous mutant lens tissue. (J:44949)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja3 Mutation:  14 strains or lines available
References
Original:  J:44949 Gong X, et al., Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997 Dec 12;91(6):833-43
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory