All Phenotypes Gja3<tm1Scr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja3^tm1Scr
targeted mutation 1, The Scripps Research Institute
MGI:2136656

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr	involves: 129 * C3H/HeJ * C57BL/6J	MGI:3811922
cx2	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3811924
cx3	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J	MGI:3811920
cx4	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G	involves: 129S4/SvJae * CWD/LeAgl * SJL/J	MGI:5489762

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (18 available)
Gja8^L1 mutation (1 available); any Gja8 mutation (31 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (18 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:108522 )

• cystic lumen

nuclear cataract ( J:108522 )

• nuclear rather than whole cataracts

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G
Genetic Background	involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (18 available)
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

vision/eye phenotype ( J:195727 )

N	• mice exhibit normal lens periphery and lens fiber unlike in Gja8^Nm2249 homozygotes

nuclear cataract ( J:195727 )

• dense

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