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Targeted Allele Detail
Symbol: Penk-rstm1Pig
Name: preproenkephalin, related sequence; targeted mutation 1, Pain Investigation Group
MGI ID: MGI:2136456
Synonyms: enk-, Penk2tm1Zim, Penk KO, PPNK-
Gene: Penk-rs  Location: unknown  Genetic Position: Chr9, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:35826
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced 54 bp of the 5' part of exon 3 and parts of the second intron. The mutated allele contains a rearrangement downstream from the insertion site with a partial duplication of exon 3 sequences. Northern blot analysis of brain and testis detected nearly no encoded mRNA in homozygous mice. (J:35826)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Penk-rs Mutation:  3 strains or lines available
Original:  J:35826 Konig M, et al., Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature. 1996 Oct 10;383(6600):535-8
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory