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Irs1tm1Jos
Targeted Allele Detail
Nomenclature
Symbol: Irs1tm1Jos
Name: insulin receptor substrate 1; targeted mutation 1, Joslin Diabetes Center
MGI ID: MGI:2136455
Synonyms: Irs1-, IRS-1-, IRS-1 KO
Gene: Irs1  Location: Chr1:82233101-82291416 bp, - strand  Genetic Position: Chr1, 42.0 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21374
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced bases -77 to + 179 of the gene, deleting the start codon and producing a shift in the reading frame. Western blots of liver and muscle extracts showed no detectable protein. (J:21374, J:169458)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs1 Mutation:  28 strains or lines available
References
Original:  J:21374 Araki E, et al., Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene [see comments]. Nature. 1994 Nov 10;372(6502):186-90
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory